Hank Azaria: Blue Raja

Janeane Garofalo: Bowler

William H. Macy: Shoveler

Kel Mitchell: Invisible Boy

Paul Reubens: Spleen

Ben Stiller: Furious

Wes Studi: Sphinx

Greg Kinnear: Captain Amazing, Lance

Geoffrey Rush: Casanova Frankenstein

Lena Olin: Dr. Anabel Leek

Eddie Izzard: Tony P

Artie Lange: Big Red

Pras Michel: Tony C

Claire Forlani: Monica

Tom Waits: Doc Heller

Louise Lasser: Violet

Ricky Jay: Vic Weems

Jenifer Lewis: Lucille