Tom Holland: Peter Parker, Spider-Man

Zendaya: MJ

Benedict Cumberbatch: Doctor Strange

Jacob Batalon: Ned Leeds

Jon Favreau: Happy Hogan

Jamie Foxx: Max Dillon, Electro

Willem Dafoe: Norman Osborn, Green Goblin

Alfred Molina: Dr. Otto Octavius, Doc Ock

Benedict Wong: Wong

Tony Revolori: Flash Thompson

Marisa Tomei: May Parker

Andrew Garfield: Peter Parker, Spider-Man

Tobey Maguire: Peter Parker, Spider-Man

Angourie Rice: Betty Brant

Arian Moayed: Agent Cleary

Paula Newsome: MIT Assistant Vice Chancellor

Hannibal Buress: Coach Wilson

Martin Starr: Mr. Harrington

Haroon Khan: Apprentice

J.B. Smoove: Mr. Dell

J.K. Simmons: J. Jonah Jameson

Rhys Ifans: Dr. Curt Connors, The Lizard

Mary Rivera: Ned's Lola

Charlie Cox: Matt Murdock

Kathleen Cardoso: Arena Bystander

Thomas Haden Church: Flint Marko, Sandman